Autoimmune Hemolytic Anemia:Focusing on Therapy According to Classification

AIHAs can be subdivided according to underlying disease (Table 1). No underlying disease or agent can be distinguished in primary AIHA, whereas in the secondary cases, an associated condition is well documented such as autoimmune diseases, malignancies, infections or drugs. Malignancies are one of the most common causes. AIHA can be seen at the diagnosis or during the course of cancers such as lymphomas, Chronic Lymphocytic Leukemia (CLL), and solid tumors. AIHA can be also associated with autoimmune diseases particularly Systemic Lupus Erythematosus (SLE). Other examples of autoimmune diseases are antiphospholipid syndrome, Sjogren’s syndrome, and rheumatoid arthritis [3-7]. Beside these, many drugs can cause AIHAs [8,9].